Introduction According to the different locations and characteristics of intracranial aneurysms, surgical approaches are determined with the aim of
maximizing exposure and safety. The pterional approach has been used as a first option for various neurosurgical disorders.1)3)4)7) This
approach, which provides the option of accessing lesions in the anterior, middle and upper posterior fossae, cavernous sinus and sellar area
was introduced and popularized in contemporary neurosurgery for the treatment of cerebral aneurysms by Ya?argil et al.7)8)22) Many traditional approaches have been widely used for the treatment of intracranial aneurysms; a common feature of these techniques is the
relatively extensive skin, bone, and brain exposure, possibly causing an increase in iatrogenic injury not related to the aneurysms itself. To
obviate these problems, many modifications of the pterional approach have been created and keyhole approaches have been developed for
use in modern microneurosurgery.9)17)21) They are designed to reduce iatrogenic traumatization by minimizing exposure and handling of
tissues, in order to achieve maximum efficacy in the treatment of neurosurgical diseases.5)6)9)18-20) We adopted a previously reported pterional approach in our surgical practice and developed the neuronavigation-guided keyhole approach to
demonstrate the efficacy of this minimally invasive procedure.11) Herein, we report our experience of using this approach in the treatment of
32 patients with unruptured cerebral aneurysms. Materials and Methods Patient population Between December 2008 and December 2010, 32 patients with unruptured intracranial aneurysms underwent direct surgical clipping through
the neuronavigation-guided keyhole approach in our hospital. Patients were selected according to the size and position of the aneurysm in
the circle of Willis. We used Vector vision compact? neuronavigation system (BrainLAB, Feldkirchen, Germany) and Star PACS? (Infinitt
healthcare, Seoul, Korea) for image registration. Because brain computed tomography (CT) is easily available, preoperative thin-slice (slice
thickness, 1 mm) brain CT with contrast enhancement was obtained for neuronavigation. The targeted aneurysm was outlined and
reconstructed in the axial, coronal and sagittal CT planes (Fig. 1B).
Operative methods The patients were placed in a supine position, with their head elevated 10° to 15° such that the head position was above the heart and was
extended to allow the frontal lobe to fall away by gravity. The head was rotated from 15° to 45° toward the opposite side of the lesion, and
was fixed by a 3-point device such as the Mayfield head holder. Anatomical landmarks, including the sylvian line and the frontozygomatic
point, were identified on the scalp before the application of the surgical drapes, for incision planning (Fig. 1A). These points were estimated
via the neuronavigation system (Fig. 1B). A 4- to 5- cm skin incision was made along the frontotemporal area 1 cm behind each patient’s
hair line, and centered at 2/3 of the estimated location of the sylvian line, in order to expose the frontal lobe more than the temporal lobe
(Fig. 1A). After the temporal muscle was incised along the skin incision, the bone was exposed following subperiosteal dissection. The
sphenoid ridge, which separates the frontal and temporal lobes, was identified. A single burr hole was made at the most distal part of the
exposed bone and centered over the sphenoid ridge (Fig. 1C). Next, a Freer elevator was used to separate the dura from the bone to
prevent dural tearing, particularly in elderly patients. The craniotomy was performed using a high-speed craniotome (Fig. 1C). An oval-
shaped craniotomy, approximately 2.5×4cm in size, was completed as described above (Fig. 1D). The lateral part of the sphenoid ridge was
drilled off using a high-speed drill. After the dura had opened in a semilunar manner and reflected (Fig. 1E), we used the neuronavigation
system to verify the actual location of aneurysm, adjust the trajectory of the sylvian dissection. The remainder of the aneurysm surgery was
performed using conventional microsurgical techniques (Fig. 1F). Generally, no drainage was left in place. The skin was closed with skin
staples. Results The 32 enrolled patients comprised 15 men and 17 women, with a mean age of 63.06 years (range, 47 to 79 years). All patients had a single
aneurysm. Of these, 21 aneurysms were in the middle cerebral artery (MCA) bifurcation; 3, in the M1; 5, in the posterior communicating artery
(PComA) segment; 2, in the anterior communicating artery and 1, in the anterior choroidal artery segment (Table 1). The size of the
aneurysms ranged from 3.5 to 4.8mm. Mean operation time and hospitalization stay were 131 minutes (range, 100 to 150 minutes) and
5.4days (range, 4 to 8), respectively. Because many patients wanted to stay in hospital, mean hospitalization stay was longer than
expected. Mean operation time and hospitalization stay in conventional pterional approach were 192minute (range, 165 to 210minutes) and
8.3days (range, 6 to 10), respectively. All aneurysms were clipped successfully. There were no severe complications related to the
neuronavigation-guided keyhole approach, including infection, hematoma, cerebrospinal fluid leakage and nerve injury. Overall, the patients
were satisfied with the cosmetic results. Discussion Various surgical approaches are available for the clipping of cerebral aneurysms. The pterional approach has been widely used, but has
several disadvantages including a large bone flap, damage to the facial nerve and trauma to the soft tissues. Since the implementation of the
minimally invasive concept in neurosurgery, several investigators have developed new techniques to decrease the size of the bone flap,
reduce brain retraction and enhance the exposure of the cranial base. Among them, the keyhole approach has shown convincing
advantages in the treatment of cerebral aneurysms.6)9)10)12-15)19) Currently, one of the most used keyhole approaches for treating
intracranial aneurysms is the subfrontal transciliary (front- olaterobasal, eyebrow) approach,5)6)10)13)16)20) which provides access to a
majority of the anterior circulation aneurysms. However, there are two main limitations to this approach.14) First, if the proximal MCA (M1)
segment is too long and the direction of the dome is lateral, clipping of some MCA bifurcation aneurysms might be difficult because the
surgical view and work are in a very deep plane and extensive dissection would be required. Furthermore, a thick blood clot around the
aneurysm would make the dissection more difficult in ruptured cases. Second, in case of PComA segment aneurysms, the angle of vision
with the eyebrow approach is more rostral than that obtained with the pterional approach and visualization of the aneurysmal neck is not
good in cases where the dome has a caudal direction. Previously, Nathal et al.14) described the sphenoid ridge keyhole approach, which is centered over the sylvian fissure, for all anterior
circulation aneurysms except for the distal anterior cerebral artery. The current procedure allows sufficient brain exposure to ensure
dissection of the sylvian fissure. We believe that the neuronavigation-guided keyhole approach is greatly useful in the treatment of MCA aneurysms. In cases of MCA
aneurysms, we were able to dissect the sylvian fissure minimally, due to exact identification of the aneurysm site using neuronavigation.
Therefore, we can reduce brain retraction, damage and operation time. Although our study restricted this approach to treat unruptured cerebral
aneurysms, less operative times and hospitalization stays as compared with standard pterional craniotomy were observed. Due to the small
size of the incision and the craniotomy, the integrity of the normal tissue was preserved. So, postoperative scalp and muscle swelling was
diminished and the patients were much more satisfied with the cosmetic results. The main disadvantage of a minimal approach is the neurosurgeon’s limited ability to manipulate instrument, especially in the case of proximal
artery aneurysm. However, the superficially located, unruptured, and small aneurysms were not difficult to manipulate and clip. We suggest that neuronavigation-guided keyhole craniotomy might be a good option for treating cerebral aneurysms. However, sufficient
surgical planning is required and patients should be carefully selected according to the position of the aneurysm in the circle of Willis,
neurological grade and the possible existence of associated pathological conditions such as cerebral hematoma, brain edema and
vasospasm. Conclusion With new concepts based on minimally invasive neurosurgery, the keyhole approach for treating cerebral aneurysms is gaining popularity.
Despite the small number of cases studied, we suggest that the neuronavigation-guided keyhole approach is safe and effective for the
treatment of anterior circulation aneurysms in selected cases. REFERENCES 1)Al-Mefty O. Supraorbital-pterional approach to skull base lesion. Neurosurgery 21:474-7, 1987 2)Alleyne CH Jr, Barrow DL, Oyesiku NM. Combined transsphenoidal and pterional craniotomy approach to giant pituitary tumors. Surg Neurol
57:380-90, 2002 3)Arnold H, Hermann HD. Skull base chordoma with cavernous sinus involvement. Partial or radical tumour-removal? Acta Neurochir (Wien)
83:31-7, 1986 4)Carrizo A, Basso A. Current surgical treatment for sphenoorbital meningiomas. Surg Neurol 50:574-8, 1998 5)Czirjak S, Nyary I, Futo J, Szeifert GT. Bilateral supraorbital keyhole approach for multiple aneurysms via superciliary skin incisions. Surg
Neurol 57:314-24, 2002 6)Czirjak S, Szeifert GT. Surgical experience with frontolateral keyhole craniotomy through a superciliary skin incisions. Neurosurgery
48:145-50, 2001 7)Day AL. Aneurysms of the opthalmic segment. A clinical and anatomical analysis. J Neurosurg 72:677-91, 1990 8)Dolenic VV. A combined transorbital-transclinoid and transsylvian approach to carotid-opthalmic aneurysms without retraction of the brain.
Acta Neurochir Suppl (Wien) 72:89-97, 1999 9)Fukushima T, Miyazaki S, Takusagawa Y, Reichman M. Unilateral interhemispheric keyhole approach for anterior cerebral artery aneurysms.
Acta Neurochir Suppl (Wien) 53:42-7, 1991 10)Grand W, Landi MK, Dare AO. Transorbital keyhole approach to anterior communicating artery aneurysms. Neurosurgery 49:483-4, 2001 11)Kang SD. Pterional craniotomy without keyhole to supratentorial cerebral aneurysms: technical note. Surg Neurol 60:457-61, 2003 12)Mori K, Osada H, Yamamoto T, Nakao Y, Maeda M. Pterional keyhole approach to middle cerebral artery aneurysms through an outer
canthal skin incision. Minim Invasive Neurosurg 50:195-201, 2007 13)Mori K, Yamamoto T, Nakao Y, Oyama K, Esaki T, Watanabe M et al. Lateral supraorbital keyhole approach to clip unruptured anterior
communicating artery aneurysms. Minim Invasive Neurosurg 51:292-97, 2008 14)Nathal E, Gomez-Amador JL. Anatomic and surgical basis of the sphenoid ridge keyhole approach for cerebral aneurysms. Neurosurgery
56:178-85, 2005 15)Paladino J, Mrak G, Miklic P, Jednacak H, Mihalijevic D. The keyhole concept in aneurysm surgery-a comparative study: keyhole versus
standard craniotomy. Minim Invasive Neurosurg 48:251-8, 2005 16)Paladino J, Pirker N, Stimac D, Stern-Padovan R. Eyebrow keyhole approach in vascular neurosurgery. Minim Invasive Neurosurg
41:200-3, 1998 17)Perneczky A, Muller-Forell W, van Lindert E. Keyhole concept in neurosurgery. With endoscope-assisted microsurgery and case studies.
ed 1, Stuttgart, Thieme Verlag, 1999, pp 1-272 18)Ramos-Zu?iga R. The trans-supraorbital approach. Minim Invasive Neurosurg 42:133-6, 1999 19)Schramm J, Kral T, Clusmann H. Transsylvian keyhole functional hemispherectomy. Neurosurgery 49:891-901, 2001 20)van Lindert E, Perneczky A, Fries G, Pierangeli E. The supraorbital keyhole approach to supratentorial aneurysms: concept and
technique. Surg Neurol 49:481-90, 1998 21)Wilson D. Limited exposure in cerebral surgery. J Neurosurg 34:102-6, 1971 22)Yasargil MG, Fox JL. The microsurgical approach to intracranial aneurysms. Surg Neurol 3:7-14, 1975
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