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J Cerebrovasc Endovasc Neurosurg. 2018 20(3): 159-167
The Journal of Cerebrovascular and Endovascular Neurosurgery
Diverse Ischemic Postconditioning Protocols Affect theInfarction Size in Focal Ischemic Stroke
Joo-Seok Lee1, Dong-Jun Song2, Jong-Hwan Hong 2, Tae-Sun Kim2, Sung-Pil Joo2
1Department of Neurosurgery, Gwangju Christian Hospital, Gwangju, Korea, 2Department of Neurosurgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea

Objective : Ischemic postconditioning (IPostC), consisted of transient brain ischemia/reperfusion cycles, is considered to have neuroprotective effect. However, there is no best single protocol of IPostC, because varied factors like species tested and characteristics of the tissue may affect the efficacy of IPostC. Thus, we investgated whether different protocols of IPostC affect neuroprotective effects in experimental animal models. Materials and Methods : Through occlusion of middle cerebral artery (MCA) with intraluminal suture, stroke was induced in a transient focal ischemia model in mice. We conducted IPostC via brief and repeated MCA occlusion, 2 minutes after reperfusion, followed by different ischemia and reperfusion protocols. After procedure, functional neurological score and histological examination were evaluated. Results : IPostC with different protocols resulted in diverse effects. Among them, a protocol that consists of 3 cycle of IPostC significantly reduced the infarction size 3 days after stroke. Conclusion : IPostC was confirmed to reduce infarction size. The effects of IPostC are definitely affected by differences in the protocol used, including the number of cycles, the duration of individual ischemia/reperfusion episode and the entire duration of the IPostC stimuli.
Key words : Ischemia, Ischemic postconditioning, Infarction, Protocol

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