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J Cerebrovasc Endovasc Neurosurg. 2016 18(3): 185-193
The Journal of Cerebrovascular and Endovascular Neurosurgery
Clinical Aspects of Cerebral Venous Thrombosis: Experiences in Two Institutions
Hyun Taek Rim1, Hyo Sub Jun1, Jun Hyong Ahn1, Ji Hee Kim1, Jae Keun Oh1, Joon Ho Song1, Byung Moon Cho2, In Bok Chang1
1Department of Neurosurgery, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea 2Department of Neurosurgery, Kangdong Sacred Heart Hospital, Seoul, Korea

Objective : Cerebral venous thrombosis (CVT) is a rare condition for which few clinical reviews have been conducted in Korea. Our aim was to investigate, risk factors, clinical presentations/courses, and outcomes of 22 patients treated for CVT at two centers. Materials and Methods : A retrospective analysis was conducted, selecting 22 patients diagnosed with and treated for CVT at two patient care centers over a 10-year period (January 1, 2004 to August 31, 2015). Patient data, pathogenetic concerns (laboratory findings), risk factors, locations, symptoms, treatments, and clinical outcomes were reviewed. Results : Mean patient age at diagnosis was 54.41 16.19. Patients most often presented with headache (40%), followed by seizure (27%) and altered mental status (18%). Focal motor deficits (5%), visual symptoms (5%), and dysarthria (5%) were less common. Important predisposing factors in CVT included prothrombotic conditions (35%), infections (14%), hyperthyroidism (18%), trauma (14%), and malignancy (4%). By location, 9 patients (40%) experienced thrombosis of superior sagittal sinus predominantly, with involvement of transverse sinus in 20 (90%), sigmoid sinus in 12 (40%), and the deep venous system in 5 (23%). Treatment generally consisted of anticoagulants (63%) or antiplatelet (23%) drugs, but surgical decompression was considered if warranted (14%). Medical therapy in CVT yields good functional outcomes. Conclusion : Mean age of patients with CVT in our study exceeded that reported in Europe or in America and had difference in risk factors. Functional outcomes are good with use of antithrombotic medication, whether or not hemorrhagic infarction is evident.
Key words : Sinus thrombosis, Venous thrombosis, Anticoagulants

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